Browse by Dewey Subject
Number of items at this level: 80.
Charlton, Jacqui, Kilbride, Lynn, MacLean, Rory D J, Darlison, Mark G and McKnight, John (2015) Can laboratory based research regarding type 1 diabetes and exercise be applied into the real-life environment? Practical Diabetes, 32 (6). pp. 217-221.
Snowden, Austyn, Young, Jenny, White, Craig, Murray, Esther, Richard, Claude, Lussier, Marie-Therese, MacArthur, Ewan, Storey, Dawn, Schipani, Stafano, Wheatley, Duncan, McMahon, Jeremy and Ross, Elaine (2015) Evaluating holistic needs assessment in outpatient cancer care--a randomised controlled trial: the study protocol. BMJ Open, 5 (5). e006840-e006840. ISSN 2044-6055
Cunniff, AnnA Louise, ChishoLm, ViVienne and Chouliara, Zoë (2015) Listening to Fathers of Sons with Duchenne Muscular Dystrophy. New Male Studies, 4 (2). pp. 5-23. ISSN 1839-7816
Smith, VVivien, Chouliara, Zoë, Morris, Paul G, Collin, Paula, Power, Kevin, Yellowlees, Alex, Grierson, David, Papageorgiou, Elena and Cook, Moira (2014) The experience of specialist inpatient treatment for anorexia nervosa: A qualitative study from adult patients' perspectives. Journal of Health Psychology. pp. 1-12. ISSN 1359-1053
Chouliara, Zoë and Affleck, Andrew G (2014) Psychological adjustment to disfiguring skin diseases . Dermatology in Practice, 20 (1). pp. 16-19. ISSN 0262-5504
Patterson, Stephen D, Leggate, Melanie, Nimmo, Myra A and Ferguson, Richard A (2013) Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. European Journal of Applied Physiology, 113 (3). pp. 713-719. ISSN 1439-6319
Affleck, Andrew, Chouliara, Zoë and Kielty, Shauna (2013) Cognitive behavioral therapy for acne and other chronic skin disorders - Letter to Editor. International Journal of Dermatology, 53 (4). e246-e247. ISSN 0011 9059
Karatzias, Thanos, Chouliara, Zoë, Power, Kevin, Brown, Keith, Begum, Millia, McGoldrick, Therese and MacLean, Rory (2013) Life satisfaction in people with post-traumatic stress disorder. Journal of Mental Health, 22 (6). pp. 501-508. ISSN 0963-8237
Chouliara, Zoë, Karatzias, Thanos, Scott-Brien, Georgia, Macdonald, Anne, MacArthur, Juliet and Frazer, Norman (2012) Adult survivors' of childhood sexual abuse perspectives of services: A systematic review. Counselling and Psychotherapy Research, 12 (2). pp. 146-161. ISSN 1473-3145
Snowden, Austyn, Marland, Glenn, Murray, Esther and McCaig, Marie (2012) Denial of heart disease, delays seeking help and lifestyle changes. British Journal of Cardiac Nursing, 7 (3). pp. 124-128. ISSN 1749-6403
Leggate, Melanie, Carter, W G, Evans, M J C, Vennard, R A, Sribala-Sundaram, S and Nimmo, Myra A (2012) Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology, 112 (8). pp. 1353-1360. ISSN 8750-7587
Reid, Lorna, Snowden, Austyn and Kydd, Angela (2012) An exploration of palliative care provision in Scottish care homes. British Journal of Nursing, 21 (1). pp. 8-15. ISSN 0966-0461
Fox, Sarah, Wilkinson, Tom S, Wheatley, Paul S, Xiao, Bo, Morris, Russell E, Sutherland, Alistair, Simpson, A John, Barlow, Peter G, Butler, Anthony R, Megson, Ian L and Rossi, Adriano G (2010) NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta Biomaterialia, 6 (4). pp. 1515-1521.
Din, Farhat V N, Theodoratou, Evropi, Farrington, Susan M, Tenesa, Albert, Barnetson, Rebecca A, Cetnarskyj, Roseanne, Stark, Lesley, Porteous, Mary E, Campbell, Harry and Dunlop, Malcolm G (2010) Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut, 59 (12). pp. 1670-1679. ISSN 0017-5749
Smith, Graeme D, Steinke, Douglas T, Penny, Kay I, Kinnear, Moira and Penman, Iain (2010) Health-related quality of life and symptom classification in patients with irritable bowel syndrome. Journal of nursing and healthcare of chronic illness, 2 (1). pp. 4-12. ISSN 1752-9816
Karatzias, Thanos, Power, Kevin, Brown, Keith and McGoldrick, Theresa (2010) Posttraumatic symptomatology and dissociation in outpatients with chronic posttraumatic stress disorder. Journal of Trauma & Dissociation, 11. pp. 83-92. ISSN 1529-9732
Leggate, Melanie, Nowell, Mari A, Jones, Simon A and Nimmo, Myra A (2010) The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones, 15 (6). pp. 827-833. ISSN 1355-8145
Karatzias, Thanos and Chouliara, Zoë (2009) Proposing a New Model of Poor Physical Health Following Psychological Trauma: The Ehlers-Clark Model and Beyond. Medical Hypotheses, 72 (4). pp. 444-447. ISSN 0306-9877
Barwell, Nicholas D, Malkova, Dalia, Leggate, Melanie and Gill, Jason M R (2009) Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization. Metabolism, 58 (9). pp. 1320-1328. ISSN 0026 0495
Li, Hsin-Ni, Barlow, Peter G, Bylund, Johun, Mackellar, Annie, Bjorstad, Ase, Conlon, James, Hiemstra, Pieter S, Haslett, Christopher, Gray, Mohini, Simpson, A John, Rossi, Adriano G and Davidson, Donald J (2009) Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages. Journal of Leukocyte Biology, 86 (4). pp. 891-902. ISSN 0741-5400
Chouliara, Zoë, Karatzias, Thanos, Dey, Laura and Goulbourne, Alison (2009) Views and experiences of young women about chlamydia in Scotland: Knowledge, condom use and access to health services. Health Psychology Update, 18 (2). pp. 14-24. ISSN 0954-2027
Barlow, Peter G, Brown, David M, Donaldson, Ken, McCallum, Janis and Stone, Vicki (2008) Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24 (3). pp. 243-252. ISSN 0742-2091
Hemming, Karla, Hutton, J, Bonellie, Sandra and Kurinczuk, Jennifer J (2008) Intrauterine growth and survival in cerebral palsy. Archives of Disease in Childhood, 93. F121-F126. ISSN 1359-2998
Tenesa, Albert, Farrington, Susan M, Prendergast, James G D, Porteous, Mary E, Walker, Marion, Haq, Naila, Barnetson, Rebecca A, Theodoratou, Evropi, Cetnarskyj, Roseanne, Cartwright, Nicola, Semple, Colin, Clark, Andrew J, Reid, Fiona J L, Smith, Lorna A, Kavoussanakis, Kostas, Koessler, Thibaud, Pharoah, Paul D P, Buch, Stephan, Schafmayer, Clemens, Tepel, Jürgen, Schreiber, Stefan, Völzke, Henry, Schmidt, Carsten O, Hampe, Jochen, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Wilkening, Stefan, Canzian, Federico, Capella, Gabriel, Moreno, Victor, Deary, Ian J, Starr, John M, Tomlinson, Ian P M, Kemp, Zoe, Howarth, Kimberley, Carvajal-Carmona, Luis, Webb, Emily, Broderick, Peter, Vijayakrishnan, Jayaram, Houlston, Richard S, Rennert, Gad, Ballinger, Dennis, Rozek, Laura, Gruber, Stephen B, Matsuda, Koichi, Kidokoro, Tomohide, Nakamura, Yusuke, Zanke, Brent W, Greenwood, Celia M T, Rangrej, Jagadish, Kustra, Rafal, Montpetit, Alexandre, Hudson, Thomas J, Gallinger, Steven, Campbell, Harry and Dunlop, Malcolm G (2008) Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40 (5). pp. 631-637. ISSN 1061-4036
Theodoratou, Evropi, Campbell, Harry, Tenesa, Albert, McNeill, Geraldine, Cetnarskyj, Roseanne, Barnetson, Rebecca A, Porteous, Mary E, Dunlop, Malcolm G and Farrington, Susan M (2008) Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants. Carcinogenesis, 29 (9). pp. 1774-1780. ISSN 0143-3334
Theodoratou, Evropi, Farrington, Susan M, Tenesa, Albert, McNeill, Geraldine, Cetnarskyj, Roseanne, Barnetson, Rebecca A, Porteous, Mary E, Dunlop, Malcolm G and Campbell, Harry (2008) Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. International Journal of Cancer, 123 (9). pp. 2170-2179. ISSN 0020 7136
Smith, Graeme D, Watson, Roger and Thompson, David R (2008) Older people and inflammatory bowel disease: a systematic review. Journal of Clinical Nursing, 17 (11c). pp. 400-406. ISSN 0962 1067
Zhang, Fan, Hong, Shuangsong, Stone, Vicki and Smith, Paula (2007) Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy. Journal of Pharmacology and Experimental Therapeutics, 323 (2). pp. 508-515. ISSN 15210103
Karatzias, Thanos, Gumley, Andrew, Power, Kevin and O'Grady, Margaret (2007) Illness appraisals and self-esteem as correlates of anxiety and affective comorbid disorders in schizophrenia. Comprehensive Psychiatry, 48 (4). pp. 371-375. ISSN 0010440X
MacMillan, Maureen, Wells, Mary, MacBride, Sheila, Raab, Gillian, Munro, Alastair and MacDougall, Hugh (2007) Randomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamation. International Journal of Radiation Oncology *Biology* Physics, 68 (3). pp. 864-872. ISSN 0167-8140
Kilbride, Lynn, Smith, Graeme D and Grant, Robin (2007) The frequency and cause of anxiety and depression amongst patients with malignant brain tumours between surgery and radiotherapy. Journal of Neuro-Oncology, 84 (3). pp. 297-304. ISSN 0167-594X
Scott, Hayley M, Hutchison, Gary R, Mahood, I Kim, Hallmark, Nina, Welsh, Michelle, De Gendt, Karel, Verhoeven, Guido, Shaugnessy, Peter and Sharpe, Richard M (2007) Role of androgens in fetal testis development and dysgenesis. Endocrinology, 148 (5). pp. 2027-2036. ISSN 0013-7227
Rae, Mick T, Gubbay, O, NaKostogiannou, A, Price, Deborah, Critchley, Hilary O D and Hillier, Stephen G (2007) Thyroid hormone signaling in human ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism, 92 (1). pp. 322-327. ISSN 0021-972X
McKinstry, Brian, Hanley, Janet, Heaney, David, McLoughlan, Lucy, Elton, Rob and Webb, David (2006) Impact on hypertension control of patient-held guideline: a randomised controlled trial. British Journal of General Practice, 56 (532). pp. 842-847. ISSN 0960-1643
Rowat, Anne M, Wardlaw, Joanna M and Dennis, Martin S (2006) Abnormal breathing patterns in stroke: relationship with location of acute stroke lesion and prior cerebrosvascular disease. Journal of Neurology Neurosurgery & Psychiatry, 78 (3). pp. 277-279. ISSN 00223050
Barnetson, Rebecca A, Tenesa, Albert, Farrington, Susan M, Nicholl, Iain D, Cetnarskyj, Roseanne, Porteous, Mary E, Campbell, Harry and Dunlop, Malcolm G (2006) Identification and survival of carriers of mutations in DNA mis-match repair genes in colon cancer. New England Journal of Medicine, 354 (26). pp. 2751-2763. ISSN 0028-4793
Husband, Jacqueline and Kennedy, Catriona (2006) Exploring the role of community palliative care nurse specialists as educators. International Journal of Palliative Nursing, 12 (6). pp. 277-284. ISSN 1357-6321
Bonellie, Sandra, Colver, Allan, Surman, Geraldine, Chalmers, James, Dolk, Helen, Hemming, Karla, King, Andy, Kurinczuk, Jennifer J, Parkes, Jackie and Platt, Mary Jane (2006) UKCP: a collaborative network of cerebral palsy registers in the United Kingdom. Journal of Public Health, 28 (2). pp. 148-156. ISSN 1741-3842
Franks, Peter, Moffatt, Christine, Doherty, Debra, Williams, Anne, Jeffs, Eunice and Mortimer, Peter S (2006) Assessment of health-related quality of life in patients with lymphedema of the lower limb. Wound Repair and Regeneration, 14 (2). pp. 110-118. ISSN 1524-475X
Pennington, C, Kilbride, Lynn, Grant, Robin and Wardlaw, Joanna M (2006) A pilot study of brain tumour growth between radiotherapy planning and delivery. Clinical Oncology, 18 (2). pp. 104-108. ISSN 0936-6555
Rowat, Anne M, Dennis, Martin S and Wardlaw, Joanna M (2006) Central periodic breathing observed on hospital admission is associated with an adverse prognosis in conscious acute stroke patients. Cerebrovascular Diseases, 21 (5-6). pp. 340-347. ISSN 1015-9770
Rowat, Anne M, Dennis, Martin S and Wardlaw, Joanna M (2006) Hypoxaemia in acute stroke is frequent and worsens outcome. Cerebrovascular Diseases, 21 (3). pp. 166-172. ISSN 1015-9770
Barlow, Peter G, Li, Yuexin, Wilkinson, Thomas S, Bowdish, Dawn M E, Lau, Y Elaine, Cosseau, Celine, Haslett, Christopher, Simpson, A John, Hancock, Robert E W and Davidson, Donald J (2006) The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology, 80 (3). pp. 509-520. ISSN 0741-5400
Barlow, Peter G, Clouter-Baker, Anna, Donaldson, Ken, MacCallum, Janis and Stone, Vicki (2005) Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and Fibre Toxicology, 2. pp. 11-24. ISSN 1743-8977
Addison, Paul (2005) Wavelet analysis of the ECG: A review. Physiological Measurement, 26 (5). pp. 155-199. ISSN 1361 6579
Bonellie, Sandra, Currie, D and Chalmers, James (2005) Comparison of risk factors for cerebral palsy in twins and singletons. Developmental Medicine & Child Neurology, 47 (9). pp. 587-591. ISSN 0012-1622
Williams, K R, NaWishart, J G, Pitcairn, T K and Willis, Diane (2005) Emotion recognition by children with Down syndrome: investigation of specific impairments and error patterns. American Journal on Mental Retardation, 110 (5). pp. 387-392. ISSN 0895 8017
Palmer, Claire, Lim, Wonil, Hastie, Peter G R, Toward, Mark, Korolchuk, Victor I, Burbidge, Stephen A, Banting, George, Collingridge, Graham L, Isaac, John T R and Henley , Jeremy M (2005) Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron, 47 (4). 487 - 494. ISSN 0896-6273
Van Valckenborgh, E, Mincher, David, Di Salvo, A, Van Riet, I, Young, Lesley, Van Camp, B and Vanderkerken, K (2005) Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia, 19 (9). 1628 -1633. ISSN 0887-6924
Dias, N, Goossens, J-F, Baldeyrou, B, Lansiaux, A, Colson, P, Di Salvo, A, Bernal, J, Turnbull, Agnes, Mincher, David and Bailly, C (2005) Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry, 16 (4). 949 - 958. ISSN 1043 1802
Barlow, Peter G, Donaldson, Ken, MacCallum, Janis, Clouter, Anna and Stone, Vicki (2005) Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155 (3). pp. 397-401. ISSN 0378-4274
Reed, M J, Addison, Paul and Robertson, C E (2005) Heart rate variability measurements and the prediction of ventricular arrhythmias. QJM, 98 (2). pp. 87-95. ISSN 1460-2725
Hand, P J, Wardlaw, Joanna M, Rowat, Anne M, Haisma, J A, Lindley, R I and Dennis, Martin S (2005) Magnetic resonance brain imaging in patients with acute stroke: feasibility and patient related difficulties. Journal of Neurology Neurosurgery & Psychiatry, 76 (11). pp. 1525-1527. ISSN 0022-3050
Palmer, Claire, Cotton, Lucy and Henley , Jeremy M (2005) The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Pharmacological Reviews, 57 (2). 253 - 277. ISSN 0031-6997
Watson, James N, Uchaipichata, Nopadol, Addison, Paul, Clegg, Gareth R, Robertson, C E, Eftestol, T and Steen, P A (2004) Improved prediction of defibrillation success for out-of-hospital VF cardiac arrest using Wavelet Transform Methods. Resuscitation, 63 (3). pp. 269-275. ISSN 0300 9572
Ramage, Lindsay and Guy, Keith (2004) Expression of C-reactive protein and heat shock protein-70 in the lung epithelial cell line A549, in response to PM10 exposure. Inhalation Toxicology, 16 (6/7). pp. 447-452. ISSN 0895-8378
Williams, Anne, Moffatt, Christine and Franks, Peter (2004) A phenomenological study of the lived experiences of people with lymphoedema. International Journal of Palliative Nursing, 10 (6). pp. 279-286. ISSN 1357-6321
Keir, Pamela Alexander, Brown, David M, Clouter-Baker, Anna, Harcus, Y M and Proudfoot, Lorna (2004) Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis. Parasite Immunology, 26 (3). pp. 137-139. ISSN 0141-9838
Brown, David M, Donaldson, Ken, Borm, Paul J, Schins, Roel P F, Dehnhardt, M, Gilmour, Peter S, Jimenez, L A and Stone, Vicki (2004) Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology. Lung Cellular and Molecular Physiology., 286 (2). L344-L353. ISSN 1040-0605
Crerar, Alison (2004) Aphasia rehabilitation and the strange neglect of speed. Neuropsychological Rehabilitation, 14 (1-2). pp. 173-206. ISSN 0960-2011
Chouliara, Zoë, Miller, Morven, Stott, David, Molassiotis, Alexander, Twelves, Chris and Kearney, Nora (2004) Older people with cancer: perceptions and feelings about information, decision-making and treatment—a pilot study. European Journal of Oncology Nursing, 8 (3). pp. 257-261. ISSN 1462 3889
Chouliara, Zoë (2004) Perceptions of older people with cancer of information, decision making and treatment: a systematic review of selected literature. Annals of Oncology, 15 (11). pp. 1596-1602. ISSN 0923-7534
Campbell, Harry, Holloway, S, Cetnarskyj, Roseanne, Anderson, E, Rush, Robert, Fry, A, Gorman, D, Steel, M and Porteous, Mary E (2003) Referrals of women with a family history of breast cancer from primary care to cancer genetics services in south East Scotland. British Journal of Cancer, 89 (9). pp. 1650-1656. ISSN 1532-1827
Moffatt, Christine, Franks, Peter, Doherty, Debra, Williams, Anne, Badger, C, Jeffs, Eunice, Basanquet, N and Mortimer, Peter S (2003) Lymphoedema: an underestimated health problem. QJM: An International Journal of Medicine, 96 (10). pp. 731-873. ISSN 1460-2393
Williams, Anne, Vadgama, A, Franks, Peter and Mortimer, Peter S (2002) A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema. European Journal of Cancer Care, 11 (4). pp. 254-261. ISSN 1365-2354
Anderson, N E, Pollacchi, Aileen, Hayes, P, Therapondos, G, Newsome, P, Boyter, A and Smith, Kevin (2002) A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. Biomedical Chromatography, 16 (6). pp. 365-372. ISSN 0269-3879
Smith, Kevin, Pollacchi, Aileen, Field, M and Watson, Julie Elizabeth (2002) The heterogeneity of the glycosylation of alpha-1-acid glycoprotein (AGP)between the sera and synovial fluid in rheumatoid arthritis. Biomedical Chromatography, 16 (4). pp. 261-266. ISSN 0269-3879
Duffin, Rodger, Gilmour, Peter S, Schins, Roel P F, Clouter, Anna, Guy, Keith, Brown, David M, MacNee, William, Borm, Paul J, Donaldson, Ken and Stone, Vicki (2001) Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation. Toxicology and Applied Pharmacology, 176 (1). pp. 10-17. ISSN 0041-008X
Lockhart, Karen (2001) Nurse-doctor collaboration in cancer pain management. International Journal of Palliative Nursing, 7 (1). pp. 8-16. ISSN 1357-6321
Penny, Kay I and Smith, Graeme D (2009) The use of data-mining to identify indicators of health related quality of life in patients with irritable bowel syndrome. In: Proceedings of the ITI 2009 31st International Conference on Information Technology Interfaces. IEEE, pp. 87-92. ISBN 978-953-7138-15-8
Chouliara, Zoë and Kearney, N (2007) Working with Older People with Cancer: Challenges in Research and Clinical Practice. In: Special Issues in Health Psychology. Livani Publishers, Athens, pp. 131-151.
Chouliara, Zoë, Karatzias, Thanos and Gullone, Angela (2013) Acts of Recovery: moving on from childhood abuse. Other. Edinburgh Napier University.
Chouliara, Zoë, Karatzias, Thanos, Gullone, Angela and Duncan, Eileen (2012) Acts of recovery: moving on from childhood abuse. (Easy read version). Other. Edinburgh Napier University.
Lightbody, Janet, Hutchison, Gary R, Donaldson, Ken and Stone, Vicki (2003) The influence of particle composition and size on in vitro and in vivo biological models. Project Report. DEFRA.
Stradling, Stephen G and Scott, Michael J (2000) Counselling for post-traumatic stress disorder. Counselling in Practice . Sage. ISBN 978-0761965732
Chiu, Wen Hsi (2011) The experience of caring of carers of cardiac surgery patients after hospital discharge. PhD thesis, Edinburgh Napier University.
Williams, Anne (2011) A qualitative study of supported self-care in women with lymphoedema associated with breast cancer. PhD thesis, Edinburgh Napier University.
Chappell, Francesca Mary (2010) Making sense of diagnostic meta-analysis using carotid artery imaging as a template. PhD thesis, Edinburgh Napier University.
Lin, Mei-Chun (2008) A comparison of carers' experiences of caring for individuals with dementia or intellectual disability: A logitudinal grounded theory study. PhD thesis, Napier University, Edinburgh, Scotland, UK.
Turnbull, Agnes (2003) Design and development of novel DNA Topoisomerase inhibitors. PhD thesis, Edinburgh Napier University.