Edinburgh Napier University

  Physical therapy is routinely delivered to patients after discharge from the hospital following knee arthroplasty (KA). Posthospitalization physical therapy is thought to be beneficial, particularly for those patients most at risk for poor outcome, the subgroup with persistent function-limiting pain despite an apparently successful surgery. Research teams have undertaken 3 large-scale multicenter Phase III randomized clinical trials designed specifically for patients at risk for poor outcome following KA. All 3 trials screened for poor outcome risk using different methods and investigated different physical therapist interventions delivered in different ways. Despite the variety of types of physical therapy and mode of delivery, all trials found no effects of the enhanced treatment as compared with usual care. In all cases, usual care required a lower dosage of physical therapy as compared with the enhanced interventions. This Perspective compares and contrasts the 3 trials, speculates on factors that may explain the no-effect findings, and proposes areas for future study designed to benefit the poor outcome phenotype.