INSPIRING FUTURES

Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome.

Usowicz, Maria M and Garden, Claire L P (2012) Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome. Brain Research, 1465. pp. 10-17. ISSN 0006 8993

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Abstract/Description

Down syndrome (DS) is characterized by intellectual disability and impaired motor control. Lack of coordinated movement, poor balance, and unclear speech imply dysfunction of the cerebellum, which is known to be reduced in volume in DS. The principal cause of the smaller cerebellum is a diminished number of granule cells (GCs). These neurons form the ‘input layer’ of the cerebellar cortex, where sensorimotor information carried by incoming mossy fibers is transformed before it is conveyed to Purkinje cells and inhibitory interneurons. However, it is not known how processing of this information is affected in the hypogranular cerebellum that characterizes DS. Here we explore the possibility that the electrical properties of the surviving GCs are changed. We find that in the Ts65Dn mouse model of DS, GCs have a higher input resistance at voltages approaching the threshold for firing, which causes them to be more excitable. In addition, they fire narrower and larger amplitude action potentials. These subtly modified electrical properties may result in atypical transfer of information at the input layer of the cerebellum.


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Item Type: Article
Print ISSN: 0006 8993
Uncontrolled Keywords: Down syndrome; Cerebellum; Granule cell; Hypoplasia
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life, Sport and Social Sciences
Dewey Decimal Subjects: 500 Science > 570 Life sciences; biology
Library of Congress Subjects: Q Science > QH Natural history > QH301 Biology
Item ID: 5507
Depositing User: Dr Claire Garden
Date Deposited: 26 Jun 2012 10:09
Last Modified: 26 Jun 2012 10:09
URI: http://researchrepository.napier.ac.uk/id/eprint/5507

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