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NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy.

Fox, Sarah, Wilkinson, Tom S, Wheatley, Paul S, Xiao, Bo, Morris, Russell E, Sutherland, Alistair, Simpson, A John, Barlow, Peter G, Butler, Anthony R, Megson, Ian L and Rossi, Adriano G (2010) NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta Biomaterialia, 6 (4). pp. 1515-1521.

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Abstract/Description

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchangedzeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchangedzeolitematerial at a 50 wt.% composition in a polytetrafluoroethylene polymer. Further to our published data showing the anti-thrombotic effects of a similar NO-loadedzeolite, this study demonstrates the anti-bacterial properties of NO-releasing zeolites against clinically relevant strains of bacteria, namely Gram-negative Pseudomonas aeruginosa and Gram-positive methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Clostridium difficile. Thus our study highlights the potential of NO-loadedzeolites as biocompatible medical device coatings with anti-infective properties

Item Type: Article
Electronic ISSN: 1742-7061
Uncontrolled Keywords: Nitric oxide; Zeolite; Anti-bacterial; Biocompatibility; Infection
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Health and Social Sciences
Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 616 Diseases
Library of Congress Subjects: R Medicine > RB Pathology
Item ID: 5172
Depositing User: Mrs Lyn Gibson
Date Deposited: 27 Mar 2012 13:37
Last Modified: 06 Dec 2012 12:09
URI: http://researchrepository.napier.ac.uk/id/eprint/5172

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