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Structure versus function: a topological perspective on immune networks.

Hart, Emma, Bersini, Hugues and Santos, Francisco (2009) Structure versus function: a topological perspective on immune networks. Natural Computing. ISSN 1567-7818

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Abstract/Description

Many recent advances have been made in understanding the functional implications of the global topological properties of biological networks through the application of complex network theory, particularly in the area of small-world and scale-free topologies. Computational studies which attempt to understand the structure–function relationship usually proceed by defining a representation of cells and an affinity measure to describe their interactions. We show that this necessarily restricts the topology of the networks that can arise—furthermore, we show that although simple topologies can be produced via representation and affinity measures common in the literature, it is unclear how to select measures which result in complex topologies, for example, exhibiting scale-free functionality. In this paper, we introduce the concept of the potential network as a method in which abstract network topologies can be directly studied, bypassing any definition of shape-space and affinity function. We illustrate the benefit of the approach by studying the evolution of idiotypic networks on a selection of scale-free and regular topologies, finding that a key immunological property—tolerance—is promoted by bi-partite and heterogeneous topologies. The approach, however, is applicable to the study of any network and thus has implications for both immunology and artificial immune system

Item Type: Article
Print ISSN: 1567-7818
Electronic ISSN: 1572-9796
Uncontrolled Keywords: Topology; complex networks; artificial immune systems; tolerance;
University Divisions/Research Centres: Faculty of Engineering, Computing and Creative Industries > School of Computing
Dewey Decimal Subjects: 000 Computer science, information & general works > 000 Computer science, knowledge & systems > 006 Special Computer Methods > 006.3 Artificial intelligence
600 Technology > 620 Engineering > 621 Electronic & mechanical engineering > 621.3 Electrical & electronic engineering > 621.38 Electronics & Communications engineering > 621.389 Computer engineering
000 Computer science, information & general works > 000 Computer science, knowledge & systems > 004 Data processing & computer science
Library of Congress Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Item ID: 3481
Depositing User: Computing Research
Date Deposited: 27 Jan 2010 11:59
Last Modified: 05 Mar 2010 12:55
URI: http://researchrepository.napier.ac.uk/id/eprint/3481

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