The impact of the shape of antibody recognition regions on the emergence of idiotypic networks.

Hart, Emma and Ross, Peter (2005) The impact of the shape of antibody recognition regions on the emergence of idiotypic networks. International Journal of Unconventional Computing, 1 (3). pp. 281-313. ISSN 1548-7199

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One of the components of an AIS algorithm that most distinguishes it from other paradigms is the use of an affinity funciton. However, for the most part, the implications of choosing a suitable matching rule and the likely effects on the algorithm from an engineering point of view have not been well studied. We develop a simulator that models an idiotypic network that can utilise a number of different shape-space models, which more faithfully model aspects of the real immune system. In each model, an antibody is considered to match any cell which lies within some volume v surrounding the point representation of the antibody (or its complement). The paper’s main contribution is to illustrate how the precise shape of the volume v influences both the dynamics of the resulting networks, and the connectivity of the networks. In particular, the shape of v radically affects the manner in which the entire shape-space can be segmented into tolerant and non-tolerant regions. This has significant bearing for the AIS-practitioner: choosing the correct model may make the difference between being able to find a successful solution to a problem or not.

Item Type: Article
Print ISSN: 1548-7199
Electronic ISSN: 1548-7202
Uncontrolled Keywords: Autonomic immune system algorithm; AIS algorithm; Idiotypic networks; Molecular shape fitting; Computer simulation;
University Divisions/Research Centres: Faculty of Engineering, Computing and Creative Industries > School of Computing
Dewey Decimal Subjects: 000 Computer science, information & general works > 000 Computer science, knowledge & systems > 006 Special Computer Methods
600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics
500 Science > 540 Chemistry > 542 Techniques, equipment & materials
Library of Congress Subjects: R Medicine > RM Therapeutics. Pharmacology
Q Science > QA Mathematics > QA76 Computer software
Item ID: 1752
Depositing User: RAE Import
Date Deposited: 26 May 2008 14:33
Last Modified: 10 Feb 2016 11:47

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