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A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases.

Anderson, N E, Pollacchi, Aileen, Hayes, P, Therapondos, G, Newsome, P, Boyter, A and Smith, Kevin (2002) A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. Biomedical Chromatography, 16 (6). pp. 365-372. ISSN 0269-3879

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Abstract/Description

During the acute phase response (APR) to tissue injury or infection, the liver is responsible for the level of mediators such as cytokines required at the site of inflammation and providing the essential components for wound healing and tissue repair. Additionally there are substantial alterations in the expression of plasma proteins of hepatic origin such as alpha-1-acid glycoprotein (AGP). The APR also results in alterations to the branching, sialylation and fucosylation of the oligosaccharide chains of AGP. This study investigated whether liver damage could be correlated with changes in AGP glycosylation in groups of patients with various liver diseases (alcoholic liver disease, hepatitis B, hepatitis C, cirrhosis). Hyperfucosylation occurred in all cases of liver disease, although the hepatitis B and C samples showed a more significant increase in comparison with the others. Additionally N-acetylgalactosamine (GalNAc) was detected in the majority of the hepatitis C samples, which was unexpected since this monosaccharide is not a usual component of the N-linked oligosaccharide chains. It was also determined by concanavalin (con) A chromatography that there is a shift towards the increased branching of the oligosaccharide chains in inflammatory liver diseases compared to normal serum.

Item Type: Article
Print ISSN: 0269-3879
Electronic ISSN: 1099-0801
Uncontrolled Keywords: acute phase response; liver; cytokines; wound healing; tissue repair; alpha-1-acid glycoprotein; sialylation; fucosylation; oligosaccharide; alcoholic liver disease; hepatitis B; hepatitis C; cirrhosis;
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 500 Science > 570 Life sciences; biology > 572 Biochemistry
600 Technology > 610 Medicine & health > 611 Human anatomy, cytology & histology
600 Technology > 610 Medicine & health > 616 Diseases
Library of Congress Subjects: R Medicine > RB Pathology
Q Science > QP Physiology
Item ID: 1673
Depositing User: RAE Import
Date Deposited: 02 Jul 2008 11:46
Last Modified: 17 Jun 2013 11:27
URI: http://researchrepository.napier.ac.uk/id/eprint/1673

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