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Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats.

McQueen, D S, Bond, S M, Smith, Paula, Balali-Mood, K and Smart, D (2004) Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats. European Journal of Pharmacology, 491 (2-3). pp. 181-189. ISSN 0014 2999

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Abstract/Description

The results of vasorespiratory studies in rats anaesthetised with pentobarbital show that (±) cannabidiol, a cannabinoid that lacks psychotropic actions and is inactive at cannabinoid (CB) receptors, does not affect respiration or blood pressure when injected (1–2000 μg; 3.2–6360 nmol i.a.). Cannabidiol in doses up to 2 mg (6360 nmol) i.a. or i.v. did not affect the fall in mean blood pressure or the increase in ventilation (respiratory minute volume) caused by capsaicin and high doses of anandamide, responses that are mediated by activation of vanilloid VR1 (TRPV1) receptors in this species. Similar results were obtained with (−) cannabidiol (30–100 μg i.a.; 95–318 nmol). It has previously been shown using human embryonic kidney (HEK) cells over-expressing vanilloid human VR1 (hVR1) receptors that cannabidiol is a full agonist at vanilloid VR1 receptors in vitro. However, in the intact rat cannabidiol lacked vanilloid VR1 receptor agonist effects. We conclude that there are substantial functional differences between human and rat vanilloid VR1 receptors with respect to the actions of cannabidiol as an agonist at vanilloid VR1 receptors. Studies in vivo show that cannabidiol lacks any significant effect on mean blood pressure or respiratory minute volume when injected i.a. or i.v., and that this cannabinoid does not modulate the vanilloid VR1 receptor-mediated cardiovascular and ventilatory changes reflexly evoked by capsaicin or anandamide in rats anaesthetised with pentobarbital.

Item Type: Article
Print ISSN: 0014 2999
Uncontrolled Keywords: Cannabidiol; Anandamide; Vanilloid VR1 receptors; Blood pressure; Ventilation
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics
500 Science > 570 Life sciences; biology > 572 Biochemistry
600 Technology > 610 Medicine & health > 612 Human physiology
Library of Congress Subjects: R Medicine > RM Therapeutics. Pharmacology
Q Science > QP Physiology
Item ID: 1658
Depositing User: RAE Import
Date Deposited: 30 Jun 2008 11:12
Last Modified: 10 May 2013 14:49
URI: http://researchrepository.napier.ac.uk/id/eprint/1658

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