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Perivascular nerves induce cardiovascular and respiratory reflexes in response to algogens in anaesthetised rats.

Smith, Paula and McQueen, D S (2004) Perivascular nerves induce cardiovascular and respiratory reflexes in response to algogens in anaesthetised rats. Neuroscience Research, 50 (3). pp. 271-281. ISSN 0168 0102

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Abstract/Description

In the present study we measured cardiovascular and respiratory reflexes evoked by administration of bradykinin and capsaicin into the hindlimb vasculature of anaesthetised rats, whilst simultaneously recording activity of sensory afferents on the adventitial surface of femoral arteries and veins. Bradykinin (0.9 nmol) and capsaicin (0.3 nmol) caused a rapid reflex fall in mean arterial pressure (delta mmHg: −37 ± 8 and −28 ± 3, respectively; P < 0.01) and an increase in respiratory minute volume (delta ml min−1: 180.0 ± 39.2 and 156.1 ± 24.5, respectively; P < 0.01), associated with an increase in neural discharge in arterial afferents (from basal 0.4 ± 0.3 to 8.5 ± 2.9 impulses s−1 following intra-arterial administration of bradykinin, P < 0.05, n = 7; from basal 0.2 ± 0.1 to 7.5 ± 3.7 impulses s−1 with capsaicin, P < 0.01, n = 18). The antagonists FR173657 and capsazepine confirmed bradykinin B2 and vanilloid VR1 receptors mediated the responses to bradykinin and capsaicin, respectively. Topical administration of algogen to the vessel surface, and electrical stimulation of the adventitia also evoked cardiovascular and respiratory responses. These data support the hypothesis that stimulation of sensory nerve endings within the hindlimb vasculature contributes to systemic cardiorespiratory reflexes in the rat.

Item Type: Article
Print ISSN: 0168 0102
Uncontrolled Keywords: Perivascular nerves; Cardiorespiratory reflexes; Bradykinin; B2 receptors; Capsaicin; VR1 receptors;
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 500 Science > 570 Life sciences; biology > 572 Biochemistry
500 Science > 590 Animals (Zoology) > 599 Mammals
500 Science > 570 Life sciences; biology > 573 Specific physiological systems in animals
Library of Congress Subjects: Q Science > QL Zoology
Q Science > QP Physiology
Item ID: 1657
Depositing User: RAE Import
Date Deposited: 23 Jun 2008 15:04
Last Modified: 09 May 2013 16:48
URI: http://researchrepository.napier.ac.uk/id/eprint/1657

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