The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Palmer, Claire, Cotton, Lucy and Henley, Jeremy M (2005) The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Pharmacological Reviews, 57 (2). 253 - 277. ISSN 0031-6997

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-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental importance in the brain. They are responsible for the majority of fast excitatory synaptic transmission, and their overactivation is potently excitotoxic. Recent findings have implicated AMPARs in synapse formation and stabilization, and regulation of functional AMPARs is the principal mechanism underlying synaptic plasticity. Changes in AMPAR activity have been described in the pathology of numerous diseases, such as Alzheimer's disease, stroke, and epilepsy. Unsurprisingly, the developmental and activity-dependent changes in the functional synaptic expression of these receptors are under tight cellular regulation. The molecular and cellular mechanisms that control the postsynaptic insertion, arrangement, and lifetime of surface-expressed AMPARs are the subject of intense and widespread investigation. For example, there has been an explosion of information about proteins that interact with AMPAR subunits, and these interactors are beginning to provide real insight into the molecular and cellular mechanisms underlying the cell biology of AMPARs. As a result, there has been considerable progress in this field, and the aim of this review is to provide an account of the current state of knowledge.

Item Type: Article
Print ISSN: 0031-6997
Electronic ISSN: 1521-0081
Uncontrolled Keywords: AMPARs; Fast excitatory synaptic transmission; Diseases; Proteins
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics
600 Technology > 610 Medicine & health > 614 Incidence & prevention of disease
600 Technology > 610 Medicine & health > 616 Diseases
Library of Congress Subjects: R Medicine > RM Therapeutics. Pharmacology
Item ID: 1656
Depositing User: RAE Import
Date Deposited: 24 Jun 2008 15:11
Last Modified: 23 Oct 2015 13:26

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