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Palmer, Claire, Lim, Wonil, Hastie, Peter G R, Toward, Mark, Korolchuk, Victor I, Burbidge, Stephen A, Banting, George, Collingridge, Graham L, Isaac, John T R and Henley , Jeremy M (2005) Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron, 47 (4). 487 - 494. ISSN 0896-6273
Full text not available from this repository. (Request a copy)Abstract/Description
It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunoprecipitate in a Ca2+-sensitive manner. Infusion of a truncated mutant of hippocalcin (HIP2-72) that lacks the Ca2+ binding domains prevents synaptically evoked LTD but has no effect on LTP. These data indicate that the AP2-hippocalcin complex acts as a Ca2+ sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.
| Item Type: | Article |
|---|---|
| Print ISSN: | 0896-6273 |
| Uncontrolled Keywords: | AMPARs; Hippocalcin; NMDAR-dependent LTDs |
| University Divisions/Research Centres: | Faculty of Health, Life & Social Sciences > School of Life Sciences |
| Dewey Decimal Subjects: | 600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics 600 Technology > 610 Medicine & health > 616 Diseases |
| Library of Congress Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Item ID: | 1655 |
| Depositing User: | RAE Import |
| Date Deposited: | 24 Jun 2008 16:33 |
| Last Modified: | 26 Jul 2010 11:56 |
| URI: | http://researchrepository.napier.ac.uk/id/eprint/1655 |
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