Hippocalcin functions as a calcium sensor in hippocampal LTD.

Palmer, Claire, Lim, Wonil, Hastie, Peter G R, Toward, Mark, Korolchuk, Victor I, Burbidge, Stephen A, Banting, George, Collingridge, Graham L, Isaac, John T R and Henley, Jeremy M (2005) Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron, 47 (4). 487 - 494. ISSN 0896-6273

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It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the β2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunoprecipitate in a Ca2+-sensitive manner. Infusion of a truncated mutant of hippocalcin (HIP2-72) that lacks the Ca2+ binding domains prevents synaptically evoked LTD but has no effect on LTP. These data indicate that the AP2-hippocalcin complex acts as a Ca2+ sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.

Item Type: Article
Print ISSN: 0896-6273
Uncontrolled Keywords: AMPARs; Hippocalcin; NMDAR-dependent LTDs
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics
600 Technology > 610 Medicine & health > 616 Diseases
Library of Congress Subjects: R Medicine > RM Therapeutics. Pharmacology
Item ID: 1655
Depositing User: RAE Import
Date Deposited: 24 Jun 2008 15:33
Last Modified: 23 Oct 2015 13:24

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