Impact of marathon running on cardiac structure and function in recreational runners.

Whyte, Greg P, George, Keith, Shave, Robert, Dawsons, Ellen, Stephenson, Claire, Edwards, Ben, Gaze, David, Oxborough, David, Forster, Jan and Simpson, Richard J (2004) Impact of marathon running on cardiac structure and function in recreational runners. Clinical Science, 108 (1). pp. 73-80. ISSN 0143-5221

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The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35±10 years; height, 1.74±0.08 m; body mass, 75.9±8.9 kg) were assessed pre- and immediately post-marathon. LV function was assessed using standard M-mode two-dimensional Doppler echocardiography and TDI (tissue-Doppler imaging) echocardiography. Serum was analysed for cTnT (cardiac troponin-T), TEAC (Trolox equivalent antioxidant capacity; a measure of total antioxidant capacity), MDA (malondealdehyde) and 4-HNE (4-hydroxynonenal). A strong relationship was observed between standard and TDI echocardiography for all functional measures. Diastolic function was altered post-marathon characterized by a reduction in E (peak early diastolic filling: 0.79±0.11 compared with 0.64±0.16 cm/s; P<0.001), an increase in A (peak late diastolic filling: 0.48±0.11 compared with 0.60±0.12 cm/s; P<0.001) and a resultant decrease in E/A (ratio of E to A; 1.71±0.48 compared with 1.10±0.31; P<0.001). Ejection fraction remained unchanged post-marathon. Thirty-two runners presented with cTnT values above the lower limit of detection for the assay (0.01 mg/l), and 20 runners presented post-marathon with cTnT values above the acute myocardial infarction cut-off value (0.05 mg/l). No significant correlations were observed between cTnT and any functional measurements. MDA (2.90±1.58 compared with 3.59±1.47 mmol/l) and TEAC (1.80±0.12 compared with 1.89±0.21 mmol/l) were significantly increased post-marathon, but were unrelated to changes in function or cTnT. In conclusion, the present study demonstrated a reduction in diastolic function and widespread evidence of minimal cardiac damage following a marathon in recreational runners. The mechanism(s) underpinning the altered function and appearance of cTnT appear unrelated to reactive oxygen species.

Item Type: Article
Print ISSN: 0143-5221
Electronic ISSN: 1470-8736
Uncontrolled Keywords: Cardiac troponin T; Echocardiography; Marathon; Tissue Doppler imaging; Reactive oxygen species; Left ventricular functioning; Oxidative stress
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 612 Human physiology
600 Technology > 610 Medicine & health > 611 Human anatomy, cytology & histology
Library of Congress Subjects: Q Science > QP Physiology
Item ID: 1637
Depositing User: RAE Import
Date Deposited: 20 Jun 2008 13:02
Last Modified: 09 Jul 2012 15:33

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