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Expression of C-reactive protein in human lung epithelial cells and up-regulation by cytokines and carbon particles.

Ramage, Lindsay, Proudfoot, Lorna and Guy, Keith (2004) Expression of C-reactive protein in human lung epithelial cells and up-regulation by cytokines and carbon particles. Inhalation Toxicology, 16 (9). pp. 607-613. ISSN 1091-7691

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Abstract/Description

C-reactive protein (CRP) is the prototypic human acute-phase protein and is found at increased levels in the blood during episodes of inflammation. CRP was generally thought to be produced only by hepatocytes; however, several studies have shown extrahepatic synthesis of CRP. A previous study showed that PM10 and ultrafine carbon black (ufCB) were able to induce CRP expression in A549 cells. This study aims to examine the factors that lead to the production of CRP in A549 cells. A549 human lung epithelial cells were treated with cytokines (interleukin 6, tumor necrosis factor , interferon , or interleukin 1) or carbon particles (CB and ufCB) for 18 h. It was found that CRP could be expressed within the cells and that CRP was secreted from the cells particularly with tumor necrosis factor , CB and ufCB treatments. It was also found that this expression of CRP with CB and ufCB treatments was dependent on nuclear factor kappa B (NFB). The expression of CRP in A549 cells may indicate an important role for CRP expression and secretion from lung epithelial cells in response to inflammatory stimuli.

Item Type: Article
Print ISSN: 1091-7691
Uncontrolled Keywords: Microbiology; Inflammation; Inflammatory substances; pm10; Ultrafine carbon black; Tumor necrosis factor; Effects; A549 cells; Lung epithelial tissue; C-reactive protein; CRP; Expression; Secretion;
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences
Dewey Decimal Subjects: 500 Science > 570 Life sciences; biology > 572 Biochemistry
600 Technology > 610 Medicine & health > 612 Human physiology
Library of Congress Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Item ID: 1626
Depositing User: RAE Import
Date Deposited: 03 Jun 2008 10:45
Last Modified: 10 May 2013 11:07
URI: http://researchrepository.napier.ac.uk/id/eprint/1626

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