Immune alterations, lipid peroxidation, and muscle damage following a hill race.

Simpson, Richard J, Wilson, Martin R, Black, James, Ross, J A, Whyte, Greg P, Guy, Keith and Florida-James, Geraint (2005) Immune alterations, lipid peroxidation, and muscle damage following a hill race. Canadian Journal of Applied Physiology: now Applied Physiology, Nutrition, and Metabolism, 30 (2). pp. 196-211. ISSN 1715-5320

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Hill races usually include large downhill running sections, which can induce significant degrees of muscle damage in a field setting. This study examined the link between muscle damage, oxidative stress, and immune perturbations following a 7-km mountainous hill race with 457 m of ascent and 457 m of descent. Venous blood samples were taken from 7 club level runners before, immediately after, and 48 hrs postrace. Samples were analysed for total and differential leukocyte counts, markers of muscle damage (CK), lipid peroxidation (MDA), and acute phase proteins (CRP; fibrinogen; a-1-ACT). The total antioxidant status (TEAC) and plasma levels of the proinflammatory cytokines IL-6, IL-8, and TNFa were also determined. Subjective pain reports, and plasma activities of CK, MDA, and circulatory monocytes reached peak values at 48 hrs postrace (p < 0.05). TEAC and the cytokine IL-8 increased immediately after the race (p < 0.05). Plasma TNF-a remained unchanged (p > 0.05). Despite the reports of muscle damage and soreness, no evidence of an acute phase response was observed (p > 0.05), which may be explained by the failure of the race to induce a plasma TNF-a response. Future studies should examine the link between muscle damage, oxidative stress, and the acute phase response following hill races of longer duration with larger eccentric components.

Item Type: Article
Print ISSN: 1715-5320
Electronic ISSN: 1066-7814
Uncontrolled Keywords: Acute-Phase proteins; Oxidative stress; Muscle damage; Immune perbutations
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Life Sciences
Dewey Decimal Subjects: 500 Science > 570 Life sciences; biology > 571 Physiology & related subjects
600 Technology > 610 Medicine & health > 612 Human physiology
Library of Congress Subjects: Q Science > QP Physiology
Item ID: 1620
Depositing User: RAE Import
Date Deposited: 29 May 2008 15:21
Last Modified: 18 Apr 2013 13:03

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