Randomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamation.

MacMillan, Maureen, Wells, Mary, MacBride, Sheila, Raab, Gillian, Munro, Alastair and MacDougall, Hugh (2007) Randomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamation. International Journal of Radiation Oncology *Biology* Physics, 68 (3). pp. 864-872. ISSN 0167-8140

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Purpose: We present the results of a randomized controlled clinical trial that evaluated the effect of a hydrogel or dry dressing on the time to healing of moist desquamation after radiotherapy to the head-and-neck, breast, or anorectal areas.

Methods and Materials: A total of 357 patients were randomized before radiotherapy to receive simple dry dressings (Tricotex) or a hydrogel (Intrasite), with Tricotex as a secondary dressing. Patients were instructed to use their dressings from the onset of moist desquamation, if it occurred.

Results: Of the 357 patients, 100 (28%) developed moist desquamation. The time to healing was significantly prolonged (hazard ratio, 0.64; 95% confidence interval, 0.42–0.99), in patients assigned to gel dressings. No evidence was found that gel dressings had a significant impact on subjectively reported skin symptoms.

Conclusion: The results of this study have not supported the routine use of hydrogels in the care of patients with moist desquamation and suggests that the healing times are prolonged, without any improvement in patient comfort.

Item Type: Article
Print ISSN: 0167-8140
Electronic ISSN: 0360-3016
Uncontrolled Keywords: Radiotherapy; Skin care; Acute toxicity; Moist desquamation; Wound healing
University Divisions/Research Centres: Faculty of Health, Life & Social Sciences > School of Nursing, Midwifery and Social Care
Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 610 Medicine & health
600 Technology > 610 Medicine & health > 616 Diseases
Library of Congress Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Item ID: 1610
Depositing User: RAE Import
Date Deposited: 02 May 2008 15:48
Last Modified: 15 Feb 2013 13:39

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